Uncapped trio Anrich Nortje, Senuran Muthusamy and Rudi Second have been included in South Africa's Test squad for the tour of India, while Quinton de Kock will captain the Twenty20 side.
Paceman Nortje, all-rounder Muthusamy and wicketkeeper-batsman Second were among the 15 players selected for a three-match series in October.
There are also three new faces in the squad for three contests in the shortest format, with batsman Temba Bavuma, spinning all-rounder Bjorn Fortuin and Nortje getting the nod.
Aiden Markram, Theunis de Bruyn and Lungi Ngidi were omitted from the T20 squad as they will be warming up for the Tests by playing in a four-day match against India A.
Faf du Plessis will continue to skipper the Test side, but he will not feature in the T20 series, so De Kock leads the side and Rassie van der Dussen will be his vice-captain.
Bavuma will be Du Plessis' deputy in the Test series, with Enoch Nkwe installed as interim team director following head coach Ottis Gibson's sacking after a poor Cricket World Cup for the Proteas.
Hashim Amla last week retired from international cricket after Dale Steyn called time on his Test career.
Test match squad: Faf du Plessis (captain) Temba Bavuma, Theunis de Bruyn, Quinton de Kock, Dean Elgar, Zubayr Hamza, Keshav Maharaj, Aiden Markram, Senuran Muthusamy, Lungi Ngidi, Anrich Nortje, Vernon Philander, Dane Piedt, Kagiso Rabada, Rudi Second (VKB Knights).
T20 squad: Quinton de Kock (captain), Rassie van der Dussen, Temba Bavuma, Junior Dala, Bjorn Fortuin, Beuran Hendricks, Reeza Hendricks, David Miller, Anrich Nortje, Andile Phehlukwayo, Dwaine Pretorius, Kagiso Rabada, Tabraiz Shamsi, Jon-Jon Smuts.